Rong Fan
Principal Investigator
Harold Hodgkinson Professor of Biomedical Engineering, Yale University
Professor of Pathology, Yale School of Medicine
Our group is focused on exploiting the systems biology principles to develop spatial technologies for comprehensive analysis of cellular and tissue heterogeneity in human health and disease. The goal is to push the understanding of complex human diseases including cancer, infectious and autoimmune diseases and transform diagnosis and therapy to enable personalized medicine.
Meet the team that makes everything happen!
Current Members
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Dongjoo Kim
Associate Research Scientist
B.S., M.S., Ph.D. Semiconductor Science and Technology, Chonbuk National University
Dongjoo has developed a nanostructure-based platform for separating specific target cells including circulating tumor cells (CTCs). After being a post-doctoral research fellow at Ulsan National Institute of Science and Technology (UNIST), he joined Professor Fan’s lab in 2016. Currently, he focused on developing a high-plex immune-serological assay and device for comprehensive evaluating immunological and serological response from COVID19 infection or vaccination.
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Mingyu Yang
Associate Research Scientist
Ph.D. Bioinformatics, Peking University
Mingyu is a bioinformatics scientist with over 10 years of experience in large-scale multi-omics data analyses including her post-doctoral training in the Fan Lab. Prior to her graduate study, she was a Bioinformatics Scientist and Group Leader at BGI-Genomics. Besides science, she enjoys music, yoga, dance, and travel.
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Bo Tao
Associate Research Scientist
Ph.D. in Pathology and Pathophysiology from Zhejiang University.
Prior to joining Fan Lab, Bo focused on researching how LDL (Low Density Lipoprotein) traverses the endothelium to initiate atherosclerosis, a process known as 'Transcytosis,' and the role of cholesterol metabolism in regulating inflammation at VBT, Yale School of Medicine under the guidance of Dr. William Sessa. During his PhD, he investigated how M2 macrophages contribute to the pathology of IPF and aging-related emphysema using various genetically modified mouse models.
At Fan Lab, Bo's interests lie in developing and applying spatial multiomics (DNA-RNA-Protein) approaches to study developmental and pathological diseases
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Fu Gao
Associate Research Scientist
MD and PhD, Peking University
Fu received his clinical training at Peking University, where he developed a comprehensive understanding of a wide range of clinical diseases. After earning his PhD/MD degree, he served as both an instructor and a physician in Peking University. Following this, he pursued postdoctoral training at Yale Medical School, further enhancing his expertise. Fu's current interests are in the development of innovative tools for spatially-resolved multi-omics. He is dedicated to applying these cutting-edge technologies to practical clinical settings.
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Zhiliang Bai
Post-doctoral Associate
B.S. Measuring and Control Technology, Tianjin University, 2015
Ph.D. Instrument Science and Technology, Tianjin University, 2021
Zhiliang worked as a visiting research assistant at Fan Lab from 2018 to 2020, during which he gained a deep passion on microfluidics, single-cell technologies, and cancer immunotherapy. He is currently working on single-cell multi-omics characterization of CAR T infusion products, the development of spatial immune repertoire technology, spatial alternative splicing profiling technology, and the next-generation spatial technology. He enjoys working out and reading books in his spare time.
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Di Zhang
Post-doctoral Associate
Di is focusing on spatial multiomics research and likes traveling in her spare time.
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Xiaolong Tian
Post-doctoral Associate
Xiaolong received his Ph.D. from Fudan University in 2022, focusing on antibody development and antibody repertoire analysis for infectious diseases. He is presently under the joint mentorship of Rong Fan and Sidi Chen, dedicating his efforts to pioneering spatial omics technologies, including spatial glycomics and spatial CRISPR. His research aims to elucidate the mechanisms underlying cancer development and to advance targeted cancer immunotherapies.
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Haikuo Li
Post-doctoral Associate
B.S. Biological Sciences (Honors Program), Shanghai Jiao Tong University, 2019
Ph.D. Molecular Genetics and Genomics, Washington University in St. Louis, 2023
Haikuo was trained in diverse biological fields including immunology, genetics, systems biology and nephrology. During his Ph.D. study advised by Dr. Ben Humphreys, Haikuo employed split-pool barcoding multiomics approaches to study kidney heterogeneity and tissue fibrosis. At the Fan Lab, Haikuo is interested in studying how gene transcription events are regulated in health and disease, and the underlying spatiotemporal dynamics and epigenetic mechanisms. He likes reading and writing outside of the lab.
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Anthony Fung
Post-doctoral Associate
PhD, UC San Diego
Anthony "Tony" received his PhD from the University of California San Diego in 2023 under the guidance of Dr. Lingyan Shi in the Shu-Chien Gene-Lay Department of Bioengineering. He studied biomedical imaging applications and analysis with a specialization in label-free vibrational spectromicroscopy modalities such as Stimulated Raman Scattering. After using the label-free multi-modal imaging platform he set up to study subcellular breast cancer metabolism and diabetic kidney disease, he co-founded Raman Noodle Inc. - a metabolic imaging contract research organization and consultation agency. Tony's current interests center on the integration of spatial omics research and microscopy modalities to elucidate the interplay between biomolecular metabolism and biological fate.
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Graham Su
PhD Student
B.S. Bioengineering, University of Illinois - Urbana-Champaign, 2018
Graham became fascinated with stem cells, cancer research, and the data science required in the biomedical field during his undergrad. His current work is on the spatial transcriptomic and multiomic mapping human and mouse hippocampus to study the regional profile and expressional mechanisms involved in several key brain functions such as memory and neuroplasticity. In his spare time, he enjoys working out, playing video games, and snowboarding.
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Xiaoyu Qin
PhD Student
B.S. Biological Sciences, University of Science and Technology of China
Xiaoyu is interested in developing new tools for spatially-resolved multi-omics sequencing, and characterizing the hematopoietic niche within its spatial context. When she’s not doing research, you may find her being outdoors, traveling, or reading about everything.
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Shuozhen Bao
PhD Student
B.Eng., Huazhong University of Science and Technology
Shuozhen is currently working on applying spatial omics techniques to cancers including glioblastoma and pancreatic ductal adenocarcinoma. She hopes one day she could help patients with the innovative techniques she develops. She enjoys playing table tennis, reading novels, and eating in her leisure time.
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Archibald Enninful
PhD Student
B.S. Biomedical Engineering, Yale University 2020
Archie first joined the Fan Lab during his undergraduate studies applying spatial omics technologies to study the mouse lymph node microenvironment. As a graduate student in the Fan Lab, his work is focused on mapping senescent cells in lymphoid tissues as part of the NIH’s Cellular Senescence Network (SenNet) Consortium. In his spare time, he enjoys cooking, and playing FIFA, and is a big fan of Liverpool FC.
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Negin Farzad
PhD Student
B.S. Medical Sciences, Shahid Behesti University, 2015
Negin gained a deep appreciation of cancer, radiotherapy and medical physics and found her passion in biomedical Engineering. In the Fan lab, she works on spatial transcriptomic and multiomic mapping human and mouse liver to profile liver zonation and study Senescence and immune cells as well as complex metabolism involved in several key liver functions. In her spare time, she enjoys working out, playing tennis, and musical instruments.
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Alev Baysoy
PhD Student
B.S. Engineering Sciences, Princeton University 2018
Alev worked as a research affiliate in both Christophe Benoist's group at Harvard Medical School and The Broad Institute until 2021. During this time, she also became an active member of The Immunological Genome Project and pursued her Master’s in Data Science. In the Fan lab, she hopes to develop spatial CRISPR-screening technology to determine spatial multiomics heterogeneity in the context of disease. When she isn’t in the lab, she likes to play ice hockey, soccer, ski and run. She also enjoys cooking, spending time with family and friends, and traveling.
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Yao Lu
PhD Student
B.S. Mathematics, Fudan University
M.S. Biostatistics, Johns Hopkins University
Before joining Fan Lab, Yao spend a few years doing research in cancer and cardiovascular disease. She is specially interested in multi-omics, spatial transcriptomics, and advanced algorithms in this field. She is now a member of the SenNet project and hopes to use spatial transcriptomics to decode secrets in aging and age-related diseases, such as cancer. She also enjoys reading novels and searching for nice restaurants in her spare time.
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Jungmin Nam
PhD Student
B.S. Bio-Convergence and Nano Science & Engineering, Yonsei University, 2022
Jungmin is working on profiling mouse lymph nodes using spatial transcriptomics and multiplexed tissue imaging. Outside of the lab, she enjoys knitting, playing the violin, pilates, and reading.
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Margaux LABROSSE
Visiting Scholar, PhD student @ RESTORE - Université Paul Sabatier, EUR CARe
M.Eng. Agronomic and Biocomputational Sciences, INP-ENSAT & INSA Toulouse, 2022
Margaux has a strong interest in biological data analysis, using it to extract key insights for understanding complex phenomena. Her current research focuses on identifying and characterizing adipose stromal cells (ASCs) that migrate from adipose tissue toward the muscle upon injury, playing a crucial role in its regeneration. She is particularly interested in deciphering the mechanisms underlying this migration and how they are altered with aging. Using spatial techniques, she aims to understand how the microenvironment, cellular interactions, and epigenetic profiles of the adipose tissue are modified during distal muscle injury and how these processes become impaired with age. In her spare time, she enjoys painting, playing video games and crocheting.
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Miao Liu
Post-doctoral Associate
B.S., Biological Sciences, Nanjing University, 2017
Ph.D., Genetics, Yale University, 2023
Miao received her Ph.D. under the guidance of Dr. Siyuan (Steven) Wang. During the Ph.D. study, Miao developed an imaging-based method named “Multiplexed Imaging of Nucleome Architectures” (MINA) that can profile 3D chromatin folding, RNA expression and protein localization in single cells in tissues. Miao further studied the evolutionary changes in 3D genome during lung and pancreatic cancer progression and explored the potential of single-cell cancer 3D genome mapping in providing candidate therapeutic targets and biological insights. Currently, Miao is interested in integrating spatial multi-omics sequencing with optical imaging techniques to study tissue development and diseases. In her spare time, she enjoys reading, writing and spending time with family and friends.
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Anusree Chakraborty
2025 PEB Intern
Anusree is majoring in Biomedical Engineering at Stony Brook University, where she is set to graduate in May 2028. Her research interests center on medical innovation, and through this lab, she has developed a strong appreciation for senescence and epigenomic research. During her time here, Anusree gained experience in image analysis using MATLAB, conducted thorough literature reviews, shadowed wet lab experiments, and deepened her understanding of senescence and core experimental and analysis techniques
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Evan Loe
2025 SenNet Intern
Evan currently studies Biomedical Engineering at the University of Wisconsin–Madison. His current research focuses on mapping cellular senescence in human and mouse liver using spatial omics technologies. Evan combines high-dimensional image analysis in MATLAB and R with insights from transcriptomic and epigenomic profiling to investigate how senescent cells contribute to liver disease. In his free time, he enjoys running in East Rock Park and the New Haven food scene.